Breadcrumbs

Dr Ryan D Martinus

Senior Lecturer (Biological Sciences)

Qualifications: BSc, MSc Waikato, PhD Massey

Personal Website: http://sci.waikato.ac.nz/about-us/people/martinus

Research Interests

I am interested in the relationships between mitochondrial stress and inflammatory responses in CNS, muscle, pancreas and reproductive processes.

Research Supervised

PhD

  • Najafzadeh, Vahid (2018). Biochemical and metabolic foundations of pluripotent stem cells in cattle.
  • Jabed, Md Anower (2012). RNAi-mediated reduction of a major ruminant specific milk allergen using a transgenic mouse model.

MSc (Research)

  • Azfar, Afreen (2018).
  • Chandra, Usharani (2017). Further elucidating the mechanisms of cytotoxicity of pterocellin A from pterocella vesiculosa using breast cancer cells and non-cancerous cells.
  • Kaur, Supreet (2016). In vitro study of heat shock protein 60 expression and mitochondrial stress in HeLa cells.
  • Wang, Alice (2015). Elucidating the modes of action of the antitumour New Zealand marine natural product Pterocellin A.

MSc

  • Newland, Julia (2015). Investigating anti-inflammatory modulators of primary glial cell inflammation.
  • Hall, Luke (2013). A model in vitro system to study Heat Shock Protein 60 (HSP60) expression in response to mitochondrial impairment in human cells.
  • Short, Matthew (2013). GFP tagged HSP60 used to investigate the translocation of HSP60 in response to mitochondrial stress in HeLa cells.
  • Tsuei, An-Chi (2010). Effects of metformin on human moncytic THP-1 cells - implications for type 2 diabetes mellitus.
  • Chou, Tzu-Wen Joy (2009). Inflammation and mitochondrial dysfunction: is HSP60 the link?
  • Gong, Bei (2009). Developing a Surface Plasmon Resonance (SPR)-based method for sub-nanomolar detecting of Heat Shock Proteins.
  • Sowry, Blair (2009). Epigenetic reprogramming of somatic cells by zygotic factors.
  • Puddick, Jonathan (2006). A comparartive proteomics approach to studying skeletal muscle mitochondria from myostatin knockout mice.
  • Collins, Tracey (2006). The role of mitochondrial oxidative stress in trophoblast cells and placentation of cloned embryos.
  • Hwang, Lisa (2006). Mitochondrial dysfunction and Inflammation in diabetic CNS.
  • Munif, Farina (2006). In vitro Investigation into the Health of Free and Encapsulated Porcine - Islet Cells Prior to Xenotransplantation.

BSc (Hons)

  • Steenkamer, Bridget (2015). The effect of physiological high glucose on HeLa cell groth, function and heat shock protein 60 (HSP60) expression.

Teaching Commitments

Expertise

Biochemistry; Biology; Molecular Biology; Science

Recent Publications

  • Martinus, R. (2019). Activation of Tnf-α from human endothelial cells by exposure of the mitochondrial stress protein (Hsp60) secreted from THP-1 monocytes to high glucose. In International Journal of Bioengineering and Life Sciences Vol. 13. Conference held in Singapore: World Academy of Science, Engineering and Technology. Retrieved from https://waset.org/abstracts/107492

  • Martinus, R. (2019). Inflammation in the diabetic endothelium: role of mitochondtrial Hsp60. Poster session presented at the meeting of International Conference on Molecular Mechanisms of Inflammation. Conference held in Trondheim, Norway.

  • Najafzadeh, V., Henderson, H., Martinus, R. D., & Oback, B. (2018). Bovine blastocyst development depends on threonine catabolism. bioRxiv. doi:10.1101/397562 Open Access version: https://hdl.handle.net/10289/12307

  • Martinus, R. (2018). Hsp60 secreted from THP-1 monocyte cells exposed to hyperglycaemic conditions induce TNF-a in HUVEC endothelial cells: implications for diabetic vascular disease. In 2018 International Congress of Diabetes and Metabolism. Conference held at Grand Hilton Seoul Hotel, Seoul, Korea.

View All research publications by Ryan Martinus

Contact Details

Email: martinus@waikato.ac.nz
Room: E.3.08
Phone: +64 7 838 4375
Cellphone: +64 274900551