Dr Ryan D Martinus

Senior Lecturer

Qualifications: BSc, MSc Waikato, PhD Massey

Personal Website:

Research Interests

I am interested in the relationships between mitochondrial stress and inflammatory responses in CNS, muscle, pancreas and reproductive processes.

Research Supervised


  • Liyanagamage, Donisha (in progress). Role of mitochondrial stress protein Hsp60 in diabetes induced neuro-inflammation.
  • Najafzadeh, Vahid (2018). Biochemical and metabolic foundations of pluripotent stem cells in cattle.
  • Jabed, Md Anower (2012). RNAi-mediated reduction of a major ruminant specific milk allergen using a transgenic mouse model.

MSc (Research)

  • Harvey, Savannah (in progress).  
  • Wilson, Shaan (in progress).  
  • Azfar, Afreen (2018).  Expression of TNF-a at mRNA level in Thp-1 cells exposed to LPS and HSP60 : Possible impact on diabetic vascular inflammation.
  • Chandra, Usharani (2017). Further elucidating the mechanisms of cytotoxicity of pterocellin A from pterocella vesiculosa using breast cancer cells and non-cancerous cells.
  • Kaur, Supreet (2016). In vitro study of heat shock protein 60 expression and mitochondrial stress in HeLa cells.
  • Wang, Alice (2015). Elucidating the modes of action of the antitumour New Zealand marine natural product Pterocellin A.


  • Pai, Rachita (in progress). Expression of heat shock protein in (HSP60) in HepG2 cells exposed to Metformin.
  • Newland, Julia (2015). Investigating anti-inflammatory modulators of primary glial cell inflammation.
  • Hall, Luke (2013). A model in vitro system to study Heat Shock Protein 60 (HSP60) expression in response to mitochondrial impairment in human cells.
  • Short, Matthew (2013). GFP tagged HSP60 used to investigate the translocation of HSP60 in response to mitochondrial stress in HeLa cells.
  • Tsuei, An-Chi (2010). Effects of metformin on human moncytic THP-1 cells - implications for type 2 diabetes mellitus.
  • Chou, Tzu-Wen Joy (2009). Inflammation and mitochondrial dysfunction: is HSP60 the link?
  • Gong, Bei (2009). Developing a Surface Plasmon Resonance (SPR)-based method for sub-nanomolar detecting of Heat Shock Proteins.
  • Sowry, Blair (2009). Epigenetic reprogramming of somatic cells by zygotic factors.
  • Puddick, Jonathan (2006). A comparartive proteomics approach to studying skeletal muscle mitochondria from myostatin knockout mice.
  • Collins, Tracey (2006). The role of mitochondrial oxidative stress in trophoblast cells and placentation of cloned embryos.
  • Hwang, Lisa (2006). Mitochondrial dysfunction and Inflammation in diabetic CNS.
  • Munif, Farina (2006). In vitro Investigation into the Health of Free and Encapsulated Porcine - Islet Cells Prior to Xenotransplantation.

BSc (Hons)

  • Steenkamer, Bridget (2015). The effect of physiological high glucose on HeLa cell groth, function and heat shock protein 60 (HSP60) expression.

Teaching Commitments


Biochemistry; Biology; Molecular Biology; Science

Recent Publications

  • Martinus, R. (2020). Diabetic vascular inflammation: role of mitochondrial stress. Poster session presented at the meeting of Diabetes: Glucose Control and Beyond. Conference held in Santa Fe Community Convention Center, New Mexico, USA.

  • Liyanagamage, D. S. N. K., & Martinus, R. D. (2020). Role of mitochondrial stress protein HSP60 in diabetes-induced neuroinflammation. Mediators of Inflammation, 2020, 8 pages. doi:10.1155/2020/8073516

  • Martinus, R. (2019). Inflammation in the diabetic endothelium: role of mitochondtrial Hsp60. Poster session presented at the meeting of International Conference on Molecular Mechanisms of Inflammation. Conference held in Trondheim, Norway.

  • Martinus, R. (2019). Activation of Tnf-α from human endothelial cells by exposure of the mitochondrial stress protein (Hsp60) secreted from THP-1 monocytes to high glucose. In International Journal of Bioengineering and Life Sciences Vol. 13. Conference held in Singapore: World Academy of Science, Engineering and Technology. Retrieved from

View All research publications by Ryan Martinus

Contact Details

Room: E.3.08
Phone: +64 7 838 4375
Cellphone: +64 274900551